毕恩巴赫对大脑干预技术的伦理反思

德国当代哲学家迪特·毕恩巴赫主要从事生物医学伦理研究，特别是他的大脑干预理论，即对脑内干细胞移植、大脑人工进化引起的伦理问题的反思，在国际上产生了一定的影响，被称为德国功利主义的代表。本文将他的大脑干预思想置于当代关于这一问题讨论的整体背景中进行分析和考察，力图做出较为客观地评价。     

氨基酸在大脑中的代谢作用研究

氨基酸作为神经递质和神经调质,是中枢神经系统刺激神经组织中肽类、蛋白质和其他生物活性成分的基础物质。对可作为神经递质和神经调质的氨基酸种类进行了介绍,并综述了其在大脑中的特异性代谢,指出氨基酸在大脑中的代谢是中枢神经系统代谢机制的重要部分。     

Economic burden in patients with ALK + non-small cell lung cancer,with or without brain metastases,receiving second-line anaplastic lymphoma kinase (ALK) inhibitors

Abstract

Aims: To describe the real-world economic burden of patients with anaplastic lymphoma kinase-positive (ALK+) non-small cell lung cancer (NSCLC) treated with post-crizotinib, second-line ALK inhibitor therapy.

Materials and methods: Retrospective analysis using data from US Optum: Clinformatics Data Mart administrative claims database. Adult patients with ALK?+?NSCLC treated with ceritinib or alectinib as second-line ALK inhibitors between 1 January 2011 and 30 September 2017 were included. Healthcare costs and resource utilization for up to 1?year of therapy were calculated on a per-patient-per-month (PPPM) basis and stratified by presence or absence of brain metastases (BM). Multivariate regression analysis was performed to identify factors associated with costs. Top ten cost drivers of non-inpatient procedure costs were recorded.

Results: One hundred and twelve patients received second-line ALK inhibitors. Total mean PPPM healthcare costs were $23,984 for all patients receiving up to 1?year of post-crizotinib, second-line ALK inhibitor therapy. Total mean PPPM costs for patients with BM on or prior to post-crizotinib, second-line ALK inhibitor therapy were 1.37-times as high as those for patients without BM (p?=?0.0406). Mean PPPM outpatient visits and inpatient hospitalization stays were higher for patients with BM versus no BM. The main cost drivers for non-inpatient procedures were radiation therapy, medications, and diagnostic radiology.

Limitations: Analyses did not include newer ALK-directed therapies. BM development after the index date (defined as the date of the first claim for a second-line ALK inhibitor) may have been misclassified as non-BM. Findings may not be generalizable to patients with no health insurance coverage.

Conclusions: Treatment of patients with ALK?+?NSCLC with ceritinib or alectinib as post-crizotinib, second-line ALK inhibitor therapy represents a high economic burden. Healthcare costs and resource utilization were significantly higher for patients with ALK?+?NSCLC with BM versus no BM.     

基于谐振式反射器的脑活动探测天线设计

设计了一款用于脑活动探测的超宽带定向天线。该天线采用了平面菱形单极天线的宽频带特性，通过缺陷地结构实现小型化。为了增强天线的定向辐射能力，设计了一种花瓣形谐振式反射器，在较宽频带内产生同相反射，并可减少剖面高度至0.1λ0。该天线整体结构具有尺寸小、重量轻的特点。对天线结构进行仿真优化并加工实测，测试结果与仿真的一致性表明了该天线具有超宽带的特点，实测阻抗带宽为0.91~2.42 GHz(91%)，且远场方向图表明了天线具有良好的定向性能，因而该天线可以应用于人脑活动探测等领域。     

Exploring the acceptance of technology for mobile shopping: an empirical investigation among Smartphone users

In this work, we evaluate the phenomenon of asymmetric perception of some nonverbal stimuli located in an aisle of a virtual store. In a stimulus detection experiment, with a number of potentially confounding variables held under control, it was found that the nonverbal stimuli utilized (belonging to the color, size, and shape families) were perceived more rapidly when placed on shelves on the left rather than on the right of the observer. This response pattern was constant regardless the nature of stimulus and the gender of observer. The experiment also showed the following sequence, in descending order of perception rapidity: color–shape–size. Our results appear consistent with the predictions of the brain laterality theory. Overall, our article provides an initial contribution to extend the results of Rettie and Brewer (Journal of Product and Brand Management 2000; 9, no. 1: 56–70) pioneering work obtained by reference to specific problems of package design to the positioning of items with respect to in-store traffic flow. Limitations and managerial implications of our work are discussed.     

国有化工企业人才流失原因及对策

在知识经济时代,人才资源是企业最宝贵的资源,是企业的核心竞争力。随着外资企业的进入,我国国有企业人才流失现象越来越严重。基于国有化工企业人才流失的特点,可以深入剖析企业人才流失的原因,从人才战略、人才保障、人文环境、人才流失预控与离职管理等方面提出国有企业人才流失的解决方案。     

国有化工企业人才流失原因及对策

在知识经济时代,人才资源是企业最宝贵的资源,是企业的核心竞争力。随着外资企业的进入,我国国有企业人才流失现象越来越严重。基于国有化工企业人才流失的特点,可以深入剖析企业人才流失的原因,从人才战略、人才保障、人文环境、人才流失预控与离职管理等方面提出国有企业人才流失的解决方案。     

河北省高校人才流失现象分析及对策研究

受经济、地域、高校整体水平等因素的影响，河北省人才流失现象日益严峻。文章在对河北省高校人才流失现状调研的基础上，分析了高校人才流失的原因，并给出了相关对策。     

高校人才流失的原因分析及对策

目前,高校人才流失现象十分严重,已经成为制约高校发展的瓶颈。薪酬水平普遍偏低,对高校管理制度的不满和失望,缺乏对教师的培训和再教育以及不和谐的人际关系等,是高校人才流失的主要因素。高校应根据实际情况,切实合理地提高教师薪酬水平,进一步完善高校管理制度,加强对教师的培训力度,改善高校内部的人际关系,为留住所需人才创造良好环境。     

红外成像检测技术在变电设备运行中的应用研究

随着科学技术的不断发展,红外线成像检测技术开始出现,并被人们广泛应用于各个行业。运用红外线成像仪和预试周期棒等红外线检测技术能够评价变电设备的运行情况,提高变电设备检修效率,使变电设备的检修模式及运行模式按照人们预想方向发展变化。红外线检测技术属于高科技技术,要有效利用红外线检测技术需要具有较高专业技术的运行人员。本文主要分析了目前红外线检测技术在变电设备里的运用现状,进而探索提高运行工作人员技能的方法。